System and method for packaging dosed quantities of solid drug portions

ABSTRACT

A system for packaging dosed quantities of solid drug portions comprises a plurality of dosing stations ( 2 ) for dispensing a dosed quantity of solid drug portions, a plurality of guiding ducts ( 7 ), a plurality of collecting containers ( 17 ) for receiving drug portions guided through the guiding ducts ( 7 ), and at least one discharge and packaging station ( 3 ) for transferring drug portions collected by each collecting container ( 17 ) to a packaging and for closing the packaging. The guiding ducts ( 7 ) are coupled to a transport means ( 6   a   , 6   b   , 8, 10, 11, 12, 15, 16 ) for moving the guiding ducts ( 7 ) along the dosing stations ( 2 ), wherein each guiding duct ( 7 ) is adapted to receive drug portions dispensed from at least one of the dosing stations ( 2 ) when the guiding duct ( 7 ) is positioned at the at least one dosing station ( 2 ), and to guide the received drug portions to an passage opening of the guiding duct ( 7 ). The collecting containers ( 17 ) are also coupled to the transport means ( 6   a   , 6   b   , 8, 10, 11, 12, 15, 16 ) so that each collecting container ( 17 ) can be positioned at the passage opening of one of the guiding ducts ( 7 ) to receive drug portions guided through the guiding duct ( 7 ).

The invention relates to a system for packaging dosed quantities ofsolid drug portions. The invention also relates to a method for dosingsolid drug portions, in particular by making use of a system accordingto the invention.

It is usually advantageous to package dosed quantities of solid drugportions, such as tablets, capsules, caplets and pills, in bags, pouchesor other types of packaging, wherein the drug portions in each bag arepacked separately per ingestion, wherein the bag is provided with userinformation, such as the day and time of day the drug portions have tobe taken. The bags for a user are generally attached to each other andsupplied rolled up in a dispenser box.

The filling of individual packages with dosed quantities of solid drugportions (batches) is increasingly being automated. A known system fordosing solid drug portions for final packaging in individual packagescomprises a plurality of supply containers respectively provided withdifferent types of drugs. After reading or entering a medicineprescription the supply containers relevant to the prescription areopened in order to allow a dosed quantity of drug portions to drop intoa central fall duct positioned under the supply containers. At thebottom of the fall duct the selectively released drug portions arecollected and forwarded to and filled in a packaging, such as a bag orpouch, after which the packaging is closed. Providing the packaging withuser information can be realized here prior to or following filling ofthe packaging. 60 packages per minute can be made up in this automatedmanner.

The known system does however have several drawbacks. A significantdrawback of the known system is that the filling frequency or rate ofthe system depends to a considerable extent on, and is limited by, the(longest) drop time of the drug portions in the fall duct, whereby thefilling frequency of the known system is limited and cannot beincreased. In other word, a filling cycle for a next bag may only startafter the filling cycle for a present bag can be expected to complete,i.e. after expiry of the maximum time expected for a drug portion tofall from the most distant (highest) supply container along the fallduct down to the bottom and the packaging. However, owing to thepermanently increasing demand for drug portions, there is a need inpractice to provide more packages of dosed quantity of drug portions perunit time.

It is an object of the invention to increase the filling frequency orrate.

This object is accomplished according to the present invention by asystem for packaging dosed quantities of solid drug portions accordingto claim 1. Moreover, this object is accomplished by a method accordingto claim 24.

The system according to the invention for packaging dosed quantities ofsolid drug portions comprises: a plurality of dosing stations fordispensing a dosed quantity of solid drug portions, a plurality ofguiding ducts coupled to a transport means for moving the guiding ductsalong the dosing stations, wherein each guiding duct is adapted toreceive drug portions dispensed from at least one of the dosing stationswhen the guiding duct is positioned at the at least one dosing station,and to guide the received drug portions to an passage opening of theguiding duct, a plurality of collecting containers coupled to thetransport means so that each collecting container can be positioned atthe passage opening of one of the guiding ducts to receive drug portionsguided through the guiding duct, at least one discharge and packagingstation for transferring drug portions collected by each collectingcontainer to a packaging and for closing the packaging.

Applying mobile combinations of guiding means and collecting containers,which in fact function as temporary packages, enables multiple medicineprescriptions to be collected in parallel (simultaneously) instead ofserially (successively), whereby the frequency for filling packages canbe increased substantially. While the dosed quantity of solid drugportions is moved through a guiding duct, e.g. drops through a falltube, the guiding duct (e.g. fall tube) and an underlying collectingcontainer can be moved in continuous manner, generally in the directionof one or more following dosing stations (e.g. vertical columns ofdosing stations) which—depending on the prescription to be followed—canoptionally be activated for the purpose of dispensing a dosed quantityof drug portions. Preferably, each collecting container is adapted tocollect one prescription generally associated with one user and a dayand time the drug portions of this prescription will have to be taken. Aprescription consists here of a predefined quantity and type of soliddrug portions, e.g. formed by tablets, capsules or pills. A supply ofdifferent types of solid drug portions is held at different dosingstations. The distance between the outlet of each dosing station and thecorresponding inlet of the guiding ducts (fall tubes) co-acting witheach dosing station is preferably substantially constant, so that thetime required for transferring drug portions from the dosing stations tothe adjacent guiding ducts (fall tubes) is substantially the same, thismaking it possible to move the guiding ducts with the collectingcontainers at substantially constant speed.

In a preferred embodiment, the dosing stations are arranged in aplurality of parallel columns, each column comprising a plurality ofdosing stations, wherein each guiding duct is adapted to receive drugportions dispensed from the dosing stations of a column when the guidingduct is positioned at the column of dosing station. Preferably, thedosing stations are arranged in a plurality of vertical columns and eachguiding duct consists of a vertical fall tube. This simplifies theconstruction of the transport means and the frame carrying the dosingstations. The width of a fall tube in the transport direction preferablycorresponds to the width of a dosing station. This allows for dosingstations having a maximum capacity with limited installation space.

The dosing stations generally take a stationary form. It is advantageoushere for a plurality of dosing stations to be positioned adjacent toeach other, this enabling simultaneous filling of a plurality ofcollecting containers. It is also advantageous for a plurality of dosingstations to be positioned above each other, whereby multiple types ofmedicine can be dispensed simultaneously to the same fall tube andsubsequently to the same collecting container, this also enhancing thefilling frequency of the system. It is particularly advantageous herefor at least a number of the dosing stations to be arranged in a matrixstructure with dosing stations arranged in multiple horizontal rows andmultiple vertical columns. It is advantageous here for the dosingstations to be positioned as closely as possible to each other, which inaddition to saving volume also results in time gains during filling ofthe collecting containers. It is further possible to envisage applying aplurality of matrix structures of dosing stations in order to furtherincrease capacity. In a particular embodiment the system comprises twomatrix structures, wherein each matrix structure comprises a pluralityof dosing stations arranged in rows and columns, and wherein dispensingsides of the dosing stations of the two matrix structures face towardeach other. Owing to such an orientation a number of fall tubes areenclosed by the two matrix structures.

In one embodiment, the collecting containers can be a part of the falltubes (forming the guiding ducts) or each collecting container can beattached or mechanically coupled to a fall tube, so that the transportmeans moves the fall tubes together with the collecting containers.However, in a preferred embodiment the transport means comprises a firstendless conveyor and a second endless conveyor, the fall tubes beingcoupled to the first endless conveyor and the collecting containersbeing coupled to the second endless conveyor. In this embodiment it ispossible to move a collecting container away from the fall tube, if thefall tube has passed all dosing stations and all dispensed drug portionsleft the fall tube and reached the collecting container.

By causing movement of the fall tubes round the two matrix structures ofdosing stations, and in this way along all dosing stations, the requireddrug portions can be collected in relatively efficient manner.

In one embodiment, the first endless conveyor comprises two parallelendless conveyor belts. In order to stabilize the movement of the falltubes, it is usually advantageous for the system to comprise a pluralityof endless conveyor belts, oriented substantially in parallel, whereineach fall tube is connected to a plurality of first conveyor belts. Thisstability, and particularly the stability in the vertical direction, canbe further increased when the system comprises at least one stationaryguide, such as a rail, for guiding the movement of the fall tubes.

In one embodiment, the system comprises drive means for driving thefirst endless conveyor and the second endless conveyor with the sametransport speed. The drive means preferably comprise at least oneelectric motor. It is advantageous here for the drive means to beadapted for simultaneous driving both the first conveyor and the secondconveyor. It is possible for this purpose to envisage the at least onefirst conveyor and the at least one second conveyor being coupledmechanically to each other. This coupling is preferably such that bothconveyors are moved in the same direction and at the same speed. In thisway, constant alignment between the fall tubes and the collectingcontainers can be guaranteed as far as possible. In one embodiment, thewidth of a collecting container in the transport direction substantiallycorresponds to the width of a guiding duct in the transport direction. Acollecting container and a fall tube lying above are however preferablynot physically connected to each other or even manufactured as onewhole, since uncoupling of the two components enhances the flexibilityof the system.

Physically separating the collecting containers from the fall tubesmakes it possible to guide the collecting containers away from the falltubes. In a preferred embodiment, the physical length of the secondconveyor is greater than the length of the first conveyor so that thenumber of collecting containers coupled to the second conveyor isgreater than the number of fall tubes coupled to the first conveyor.This makes it possible to guide the collecting containers along one ormore other types of (special) dosing stations for direct dispensing ofdrug portions to the collecting containers, so not via the fall tubes.These special dosing stations can advantageously be used for instancewhen special drug portions, being drug portions which are dosed lessfrequently, are applied. In an advantageous embodiment each specialdosing station comprises a supply drawer coupled to a carrier frame insuch a way that the supply drawer can be displaced. It is possible hereto envisage applying a plurality of such supply drawers coupledmechanically to each other. This makes it possible to position onesupply drawer above the collecting containers for the purpose ofdispensing drug portions, while another supply drawer is positioned agreater distance from the collecting containers to enable refillingthereof. It is advantageous for this purpose that each supply drawer iscoupled detachably to the (same) carrier frame.

The first conveyor and second conveyor will generally have asubstantially horizontal progression. It is advantageous for each falltube to be coupled to the first conveyor in a suspended manner. This isbecause the first conveyor will generally be formed by a belt tensionedrelatively tightly round two or more guide wheels, wherein each guidewheel rotates about a vertical shaft, whereby the bearing surface(width) of the belt extends in a substantially vertical direction andcan function for the purpose of carrying the fall tubes in relativelystable manner. It is possible here to envisage, and usuallyadvantageous, that each fall tube is coupled detachably to the firstconveyor, this facilitating replacement and maintenance of the falltubes. For the same reason it is advantageous for each collectingcontainer to be coupled in suspended manner to the second conveyor. Itis also advantageous here for each collecting container to be coupleddetachably to the second conveyor in order to facilitate replacement andmaintenance.

A collecting container will generally be deemed a drug portion carriagefunctioning for the purpose of collecting a prescription andtransporting the collected drug portions to the discharge and packagingstation. It is usually advantageous here for an upper side of eachcollecting container to take an open form and be adapted to receive adosed quantity of drug portions falling out of a dosing station via afall tube. The collecting container hereby also acquires the function ofcollecting tray. An underside of each collecting container preferablycomprises a controllable closing element to enable removal of thecollected drug portions. The closing element can be mechanicallycontrollable in the discharge and packaging station. The closing elementis however preferably controllable in contactless manner, morepreferably by applying magnetism. At least a part of the closing elementmust however be given a magnetic or magnetisable form for this purpose.Operation of the closing element of such a type can for instance berealized by applying an electromagnet or permanent magnet in thedischarge and packaging station. In an advantageous embodiment thecollecting container comprises biasing means, such as for instance acompression spring, for urging the closing element in the direction of aclosed state, whereby erroneous opening of the closing element can beprevented. The discharge station can in fact form part of the packagingstation, wherein dispensing of drug portions collected in a collectingcontainer to a packaging for closing can be followed almost immediatelyby closing of said packaging.

Since each collecting container collects its own prescription, it isdesirable to know the location of the fall tubes and the collectingcontainers relative to the dosing stations. For this purpose, use can bemade of a calibrating module for calibrating the position of at leastone fall tube relative to the first conveyor and/or at least onecollecting container relative to the second conveyor. The system can becalibrated by determining a reference or calibration point of at leastone fall tube and/or collecting container, since the sequence and thetransport speed of the fall tubes and the collecting containers arepre-known, as is the length of the first conveyor and the secondconveyor. Recognition of a fall tube and/or collecting container by thecalibrating module can for instance take place by providing the falltube and/or collecting container with a unique label. It is however alsopossible to envisage not labelling the fall tubes and/or collectingcontainers, but to deem the fall tube and/or collecting containerdetected at a determined moment by the calibrating module as fall tubeand/or collecting container serving as reference.

As already stated, at least a number of dosing stations are arrangedadjacent to each other, this facilitating filling of a number of—alsomutually adjacent—collecting containers. It is advantageous here for thewidth of a collecting container to substantially correspond to the widthof a fall tube, and for the width of a fall tube to substantiallycorrespond to the width of a dosing station, whereby the (mutuallyadjacent) dosing stations on the one hand and the (mutually adjacent)collecting containers on the other can be properly aligned relative toeach other, this enhancing the reliability of the filling process. Atypical width for dosing station, fall tube and collecting container is80 mm.

The packaging station is preferably adapted to seal the packaging.Sealing is understood to mean substantially medium-tight closure of thepackaging in order to enable the best possible preservation of thepackaged drug portions. A (plastic) foil will generally be applied aspackaging material and the seal will be formed by a welding process. Aseparate adhesive, in particular glue, can optionally be applied insteadof a weld for the purpose of sealing the packaging. The packagingstation is more preferably adapted to realize at least one longitudinalseal and at least one transverse seal, whereby bags are formed which aremutually connected and which in this way form a strip. Because thepackaging station is preferably adapted to realize a transverse seal,the length of the bag to be formed can be determined and preferably madedependent on the number and/or the type of drug portions to be packagedin a bag. The packaging station will generally be placed a (horizontal)distance from the dosing stations, whereby heat generated by thepackaging station will not be transferred, or hardly so, to the dosingstations and the drug portions held therein, this increasing theshelf-life of the drug portions. The packaging station is usually alsoprovided with a printer for arranging a specific label on each formedpackaging.

Each dosing station preferably comprises at least one supply containerfor drug portions, e.g. in tablet or capsule form, and a dosing deviceconnecting to the at least one supply container. The dosing station assuch is usually also referred to as a canister. The dosing device isadapted to separate one or more single drug portions from the drugportions present in the supply container. Dosing can take place byselectively removing the separated drug portions, generally by allowingthem to fall, from the dosing device. In an advantageous embodiment thedosing device is displaceable relative to the supply container between aloading state, in which a receiving space of the dosing device connectsto a delivery opening of the supply container, and an unloading state inwhich the dosing device covers the delivery opening and is adapted todeliver the separated drug portion to a collecting container coupled tothe conveyor. The dosing device will generally be of substantiallycylindrical form, wherein the one or more receiving spaces are arrangedin the cylindrical dosing device, wherein each receiving space isgenerally adapted to temporarily hold one drug portion. Such a dosingdevice is usually also referred to as an individualizing wheel. By meansof axial rotation of the cylindrical dosing element the dosing elementcan be displaced between a loading state, in which a receiving space ofthe dosing device is aligned with a delivery opening of the supplycontainer, and an unloading state in which the dosing device covers thedelivery opening and is adapted to deliver the separated drug portion toa fall tube coupled to the first conveyor. In a particular preferredembodiment, the dosing station comprises an electric motor, inparticular a servo motor or stepper motor, for displacing the dosingdevice relative to the supply container. A stepper motor is particularlysuitable for the present invention because the number of rotations madethereby, and therefore also the displacement of the dosing device, canbe regulated very precisely. When, as described above, use is made of anelectrical drive, a measuring element (sensor) can be applied to measurethe resistance produced and/or the current consumed by the electricmotor, whereby it is possible to detect whether a drug portion hasbecome jammed between the supply container and the dosing device. Thedosing device preferably comprises here at least one indicator, such asa lamp, for generating a signal when the degree of filling of the supplycontainer falls below a predefined minimum value. For the purpose ofcontrolling the electronics in the dosing station, the dosing stationpreferably comprises a station control for dispensing a dosed quantityof drug portions on demand. The station control can be particularlyadapted here to reverse the electric motor if the resistance detected bythe measuring element exceeds a predefined value. In the case a drugportion is jammed between the supply container and the dosing device thedirection of displacement of the dosing device can thus be reversed,whereby the jam can be resolved. Each supply container will generallycomprise an housing and a cover closing the housing. It is advantageoushere for an outer side of the housing to be provided with at least onereceiving space for a medicine in tablet form which is representative ofthe drug portions in tablet form received in the housing. The receivingspace can be covered here, for instance by a transparent element, suchthat the pill or tablet received in the receiving space is directlyvisible from outside, whereby it is immediately apparent which type ofmedicine is being held by the supply container. Arranging of thereceiving space in the housing is preferred to arranging of thereceiving space in the cover, since the cover is generally not connectednon-detachably to the housing and can thus be exchanged for anothercover, which could result in an incorrect indication of the content ofthe supply container and, as a consequence, hazardous situations. Thedosing device preferably comprises at least one sensor for detecting themoment at which a drug portion (e.g. medicine in tablet form) dispensedby the dosing station falls. Not only can the correct operation of thesupply container, and in particular a dosing device received therein, bedetermined on the basis of detection of this falling moment, it is alsopossible to monitor that a supply container is no longer delivering drugportions and is therefore normally empty. If the sensor detects thatinsufficient medicine is being delivered to the fall tube, andsubsequently to the collecting container, the entire content of the falltube in the dispensing station will be discarded, after which—followingfilling of the empty dosing station and/or activation of another dosingstation with the same type of medicine—the same prescription will onceagain be collected in a collecting container. It is possible in this wayto prevent drug portions with different use-by dates being placed in thesame packaging, this being undesirable from a health viewpoint.

The number of collecting containers is preferably greater than thenumber of columns of dosing stations. In a typical embodiment of thesystem according to the invention, the system comprises up to 3,000columns of dosing stations and up to 4,500 collecting containers. In apreferred embodiment the system comprises 500 columns of dosing stationsand 750 collecting containers. An advantageous ratio of the number ofcollecting containers to the number of columns of dosing stations is3:2. Different dosing stations are provided here with different soliddrug portions. It is however also possible to envisage a supply offrequently-used drug portions, such as paracetamol, being held in aplurality of dosing stations.

It is usually advantageous for the system to comprise at least onecleaning station for periodic cleaning of empty fall tubes and/orcollecting containers. The cleaning station can connect here to thefirst conveyor and/or the second conveyor, whereby the fall tubes and/orthe collecting containers need not be uncoupled. Cleaning of empty falltubes and/or collecting containers can take place each time an emptyfall tube and/or collecting container passes the cleaning station. Thecollecting containers will however generally be cleaned once every 8-36hours in the cleaning station. Cleaning preferably takes place byapplying acetone (propanone) in order to remove possible medicineresidues. Blowing the medicine residues out of the collecting containerswith air is also an option, but is usually less recommended because theblown about medicine residues can then find their way relatively easilyinto other collecting containers, and this is undesirable.

The system preferably comprises a control unit for controlling at leastthe discharge and packaging station, the dosing stations, the firstconveyor and the second conveyors. It is advantageous here for thecontrol unit to be adapted to determine, on the basis of a desired dosedquantity of drug portions for packaging, a dosed quantity of drugportions to be successively dispensed through time by a plurality ofdosing stations via the fall tubes to the collecting containers. Becauseprescriptions are taken as starting point, a logistical conversion mustbe made to a—most efficient—method of filling the collecting containers,which conversion can be made using the control unit. The control unitcan comprise a computer provided with a computer program, the computerprogram being adapted to determine a filling schedule for filling thecollecting containers and subsequently the packages in the packagingstation.

In addition, the method according to the invention for dosing solid drugportions, in particular by making use of a system according to theinvention, comprises of: A) receiving a prescription with a desiredquantity of solid drug portions, B) determining on the basis of theprescription the quantity of solid drug portions to be dispensed by atleast one dosing station to a selected collecting container, C) movingthe guiding ducts by the transport means and having the dosing stationsdispense the determined quantity of drug portions to a guiding ductmoving along the respective dosing stations for the purpose of guidingthe dispensed solid drug portions to the selected collecting container,D) having the collecting container moved via the transport means to adischarge and packaging station, and E) having the dosed quantity ofsolid drug portions delivered by the collecting container into thedischarge and packaging station. During step E) the dosed quantity ofsolid drug portions delivered by the collecting container is generallypackaged here in a packaging optionally already provided with userinformation. Advantages and embodiment variants of the method accordingto the invention have already been discussed at length in the foregoing.During step A) a plurality of prescriptions are generally received,wherein during step B) each prescription is linked to a selectedcollecting container. A plurality of dosing stations are generally alsoapplied, wherein during step C) a dosed quantity of drug portions isdispensed simultaneously by a plurality of dosing stations via at leastone guiding duct (e.g. fall tube) to selected collecting containers. Inan embodiment variant, determining the quantity of drug portions to bedispensed by at least one dosing station to a selected collectingcontainer on the basis of the prescription during step B) takes placeusing a control unit. Use is generally also made here during step B) ofa computer program comprising program instructions for performing therequired calculation with a computer. The control unit and the computercan be at least partially integrated with each other here. The number ofdrug portions dispensed by each dosing station is preferably countedduring step C). In this way it is possible to monitor whether a dosingstation is empty, and it is also possible to calculate how many drugportions the dosing station still has in store. The drug portionscollected by a collecting container during step E) are generallydiscarded if during step C) too few solid drug portions have beendispensed to the associated collecting container. It is not recommendedto replenish this incomplete prescription with a similar type of themissing solid drug portion from another dosing station, so that the sametype of solid drug portion has the same use-by date in the finalpackaging.

Preferred and/or advantageous embodiments of the invention arecharacterized in the dependent claims.

The invention will be elucidated on the basis of non-limitativeexemplary embodiments shown in the following figures. Herein:

FIG. 1 is a first perspective view of a system according to theinvention for transporting dosed quantities of solid drug portions froma plurality of dosing stations to a packaging station,

FIG. 2 is a second perspective view of the system according to FIG. 1,

FIG. 3 is a bottom view of the system according to FIG. 1,

FIG. 4 is a side view of the system according to FIG. 1,

FIG. 5 is a perspective view of the system 1 as shown in FIGS. 1-4,

FIG. 6 is a perspective rear view of a dosing station for use in asystem as shown in FIGS. 1-4,

FIG. 7 is a perspective front view of the dosing station as shown inFIG. 6,

FIG. 8 is a perspective view of a collecting container for use in asystem 1 as shown in FIGS. 1-4,

FIG. 9 is a side view of the collecting container according to FIG. 8,

FIG. 10 is a perspective front view of the discharge and packagingstation as applied in a system as shown in FIGS. 1-4,

FIG. 11 is a perspective rear view of the discharge and packagingstation according to FIG. 10,

FIG. 12 shows a fall tube as applied in a system according to FIGS. 1-4,and

FIG. 13 is a schematic example of the control of four dosing stations onthe basis of four prescriptions received for four patients.

FIGS. 1 and 2 show different perspective views, FIG. 3 shows a bottomview and FIG. 4 shows a side view of a system 1 according to theinvention for transporting dosed quantities of solid drug portions froma plurality of dosing stations 2 to a packaging station 3. System 1comprises for this purpose a support structure 4 (frame) to which aplurality of dosing stations 2 are connected in stationary, detachablemanner. Each dosing station 2 is adapted here to hold a supply of a typeof drug (pharmaceutical). Different dosing stations 2 will generallyhold a supply of different types of drugs, although it is also possibleto envisage frequently-dosed drugs being held by a plurality of dosingstations 2. The majority of the number of applied dosing stations 2 arearranged in two matrix structures 5 (of which only a single matrixstructure is shown in the figures), which matrix structures 5 togetherenclose a part of two first horizontally running conveyor belts 6 a, 6 bfor guiding ducts in the form of fall tubes 7. Fall tubes 7 are mounteddetachably here on mounting elements 8 forming part of both firstconveyor belts 6 a, 6 b. In the shown exemplary embodiment only a fewfall tubes 7 are shown, although in practice each mounting element 8will generally be connected to a fall tube 7, whereby the first conveyorbelts 6 a, 6 b are provided all the way round with fall tubes 7. Thefirst conveyor belts 6 a, 6 b are driven by drive wheels 9 which arecoupled by means of a vertical shaft 10 to an electric motor 11. Inorder to be able to counter slippage of conveyor belts 6 a, 6 b therunning surfaces 12 of the drive wheels take a profiled form. Throughdriving of the first conveyor belts 6 a, 6 b the fall tubes 7 can beguided along the dosing stations 2 arranged in matrix structures 5 forthe purpose of receiving dosed quantities of drug portions dispensed bydosing stations 2. Each fall tube 7 is adapted here for simultaneousco-action with a plurality of dosing stations 2 positioned above eachother. Each fall tube 7 is provided for this purpose with a number ofpassage openings (or inlet openings) 13 corresponding to the number ofdosing stations 2 in a vertical column, with which fall tube 7 willsimultaneously co-act. Fall tube 7 is also provided with several breakwalls 14 for limiting the maximum length of the free fall of fallingsolid drug portions, in order to limit the falling speed, and therebylimit damage to the falling drug portions (see FIG. 12). Use isgenerally made here of a maximum free-fall length of 20 cm. System 1also comprises a second conveyor belt 15 provided with mounting elements16 on which a plurality of collecting containers 17, also referred to asdrug carriages, are detachably mounted. Each mounting element 16 willgenerally be provided here with a collecting container 17 adapted fortemporary storage of a dosed quantity of drug portions made up inaccordance with a prescription. Not all collecting container 17 areshown in the figures. The second conveyor belt 15 is coupledmechanically to first conveyor belts 6 a, 6 b and is also driven byelectric motor 11, wherein the direction of displacement anddisplacement speed of conveyor belts 6 a, 6 b, 15 are the same. It ismoreover advantageous for the first conveyor belts 6 a, 6 b and thesecond conveyor belt 15 to be mutually aligned, wherein mountingelements 8, 16 lie in a substantially vertical line (directly under eachother). The distance between adjacent mounting elements 8, 16 amounts to80 mm, this substantially corresponding to the width of collectingcontainers 17, fall tubes 7 and dosing stations 2. Collecting containers17 are adapted to receive drug portions falling through fall tubes 7.Each fall tube 7 is provided for this purpose on an underside with apassage opening for falling drug portions. For a part of the transportroute, each collecting container 17 will be positioned here directlyunder a fall tube 7. In order to be able to prevent as far as possiblesagging of conveyor belts 6 a, 6 b, 15 due to the weight of respectivelyfall tubes 7 and collecting containers 17, conveyor belts 6 a, 6 b aretensioned under a bias of about 600 N. Conveyor belts 6 a, 6 b, 15 aregenerally manufactured from a relatively strong plastic such aspolyamide (nylon). As shown in the figures, the second conveyor belt 15is longer than each of the first conveyor belts 6 a, 6 b. The advantagehereof is that collecting containers 17 can be transported further alongand/or under one or more special dosing stations (not shown), preferablyformed by drawers, provided with special—less frequentlyadministered—drug portions, which special dosing stations 2 are adaptedfor direct delivery of selected drug portions to collecting containers17, so not via fall tubes 7. Collecting containers 17 will then beguided in the direction of the discharge and packaging station 3 wherethe drug portions collected in accordance with prescription aredischarged from collecting containers 17, wherein the drug portions aretransferred to an opened foil packaging 18. In packaging station 3 thefoil packaging 18 will be successively sealed and provided with specific(user) information. The overall control of system 1 is realized byapplying a control unit 19.

FIG. 5 is a perspective view of support structure 4 provided withconveyor belts 6 a, 6 b, 15 of system 1 as shown in FIGS. 1-4, this infact forming the heart of the system 1 on which fall tubes 7 andcollecting containers 17 are mounted and around which dosing stations 2are then positioned on both longitudinal sides of support structure 4.

FIG. 6 is a perspective rear view of a dosing station 2 for use in asystem 1 as shown in FIGS. 1-4. Dosing station 2 is also referred to asa canister, formed by a unit which can be coupled detachably to supportstructure 4 and which comprises a housing 20 and a cover 21 closing thehousing 20. The housing is preferably manufactured at least partiallyfrom a transparent material so that the degree of filling of dosingstation 2 can be determined without opening dosing station 2. An outerside of housing 20 is provided with a receiving space 22 for a tablet orpill (drug portion) corresponding to tablets or pills held in thehousing. Receiving space 22 is covered by means of a transparent coverelement 23. A person can hereby see immediately with which tablets orpills the dosing station 2 has to be filled. In the perspective frontview of dosing station 2 as shown in FIG. 7 the housing 20 is shownpartially transparently in order to make visible the inner mechanism ofdosing station 2. Accommodated as shown in housing 20 is an axiallyrotatable individualizing wheel 24 which is detachably connected tohousing 20 and which is adapted during axial rotation to separate asingle tablet or single pill which can subsequently be removed fromhousing 20 via a fall guide 25 arranged in the housing and can betransferred to a passage opening 13 of a fall tube 7 connecting ontofall guide 25. Individualizing wheel 24 is provided here with aplurality of receiving spaces 26 for pills or tablets distributed overthe edge periphery. The size of receiving spaces 26 can generally beadapted to the size of the pills or tablets to be held in supply.Individualizing wheel 24 can be rotated axially by means of an electricmotor 27 also accommodated in housing 20. Arranged in fall guide 25 is asensor 28 which can detect the moment at which a pill or tablet forseparation falls, and thereby also whether housing 20 has been emptied.Dosing stations 2 are visible from an outer side of system 1 andaccessible for possible replenishment of dosing stations 2. Housing 20will generally be provided with multiple LEDs (not shown) to enableindication of the current status of dosing station 2, and particularlyin the case that dosing station 2 has to be replenished or isfunctioning incorrectly.

FIG. 8 is a perspective view and FIG. 9 is a side view of a collectingcontainer 17 for use in system 1 as shown in FIGS. 1-4. Collectingcontainer 17 comprises here a mating mounting element 29 for co-actionwith mounting element 16 of the second conveyor belt 15. In order toincrease the stability of collecting container 17, the collectingcontainer 17 also comprises two securing gutters 30 a, 30 b for clampingor at least engaging round the second conveyor belt 15. An upper side ofcollecting container 17 takes an opened form and has a funnel-like shapeso that it can receive solid drug portions falling out of a fall tube 7.An underside of collecting container 17 is provided with a pivotableclosing element 31 provided with an operating tongue via which theclosing element 31 can be pivoted to enable opening, and therebyunloading, of collecting container 17. Collecting container 17 willgenerally be provided with a biasing element (not shown), such as acompression spring, in order to urge closing element 31 in the directionof the position closing the collecting container 17, whereby erroneousopening of collecting container 17 can be prevented.

FIGS. 10 and 11 respectively show a perspective front view andperspective rear view of the discharge and packaging station 3 asapplied in system 1 as shown in FIGS. 1-4. Packaging station 3 comprisesa foil roll 32 which can be unwound by means of an electric motor 33,after which the unwound foil 34 is guided via a plurality of guiderollers 35 in the direction of the collecting containers 17 to beemptied. The transport direction of foil 34 is indicated by means ofarrows in both FIGS. 10 and 11. Before foil 34 is transported below acollecting container 17 for emptying, foil 34 is provided with alongitudinal fold, whereby a V-shaped fold 36 is created in which thedrug portions can be received following opening of collecting container17. Foil 34 can be provided with two transverse seals and a longitudinalseal to enable complete sealing of packaging 18. Applied in making thelongitudinal seal are two heat bars 37, of which only one heat bar 37 isshown, and which press on either side of the two foil parts to beattached to each other, whereby the foil parts fuse together and thelongitudinal seal is formed. It is advantageous here for each heat bar37 to engage foil 34 via a stationary strip manufactured from plastic,in particular Teflon, or displaceable band 38 in order to preventadhesion of heat bars 37 to the foil. The transverse seals are alsocreated by two upright rotatable heat bars 39 which co-act with eachother and press the foil parts against each other in realizing atransverse seal. Packaging 18 can optionally be further provided with alabel. Successive packages 18 remain mutually connected in the firstinstance and together form a packaging strip.

FIG. 12 shows a fall tube 7 provided with two mating mounting elements40 a, 40 b for co-action with mounting elements 8 of the two firstconveyor belts 6 a, 6 b as applied in a system 1 according to any of theFIGS. 1-4. A particular feature however of the fall tube 7 shown in FIG.12 is that fall tube 7 is provided with an additional central guideelement 41 for co-action with a stationary guide 42 which can beattached to support structure 4 of system 1, whereby additionalstability is imparted to fall tube 7 and both first conveyor belts 6 a,6 b.

FIG. 13 shows a schematic and simplified example of the control of fourdosing stations 43 (A, B, C, D) on the basis of four prescriptionsreceived for four patients (1, 2, 3, 4). Applied for the sake of clarityin this simplified example are only four collecting containers 44,wherein each collecting container 44 is assigned to a specific patientand is thus used to collect a prescription for this patient. For thesake of convenience the fall tubes, which in fact couple dosing stations43 to collecting containers 44, are omitted. Collecting containers 44are coupled to a conveyor belt and in this way pass the different dosingstations 43. In this example the patients require the followingquantities of medicine (A, B, C, D) (see table).

Medicine Patient A B C D 1 0 1 1 2 2 2 2 0 1 3 0 1 0 1 4 1 2 3 4

It follows from the table that patient 1 for instance requires notablets of medicine A, one tablet of medicine B, one tablet of medicineC and two tablets of medicine D. FIG. 13 shows seven different positionsI-VII of the train of collecting containers 44. In position I thecollecting container 44 of patient 4 is positioned under dosing station43 filled with medicine A, whereby dosing station 43 will allow onetablet A to drop into collecting container 44 of patient 4. In positionII collecting container 44 of patient 4 is positioned under dosingstation 43 filled with medicine B, and collecting container 44 ofpatient 3 is positioned under the dosing station filled with medicine A.In this position II two tablets B will be deposited into collectingcontainer 44 of patient 4; since patient 3 does not require a tablet A,the associated dosing station 43 will remain inactive. The followingconversion can in this way be made to position-dependent dosages (seetable).

A B C D I 1 0 0 0 II 0 2 0 0 III 2 1 3 0 IV 0 2 0 4 V 0 1 0 1 VI 0 0 1 1VII 0 0 0 2

The prescriptions of the different patients can be found here in adiagonal line (from top left to bottom right). Dosing stations 43 areactivated on the basis of the above-stated analysis. Dosing station 43can be activated at the correct moment on the basis of determining areference position of a first collecting container 44, the transportspeed of collecting containers 44 and the length of the conveyor belt.

It will be apparent that the invention is not limited to the exemplaryembodiments shown and described here, but that numerous variants whichwill be self-evident to the skilled person in this field are possiblewithin the scope of the appended claims.

1. A system for packaging dosed quantities of solid drug portions,comprising: a plurality of dosing stations for dispensing a dosedquantity of solid drug portions, a plurality of guiding ducts coupled toa transport means for moving the guiding ducts along the dosingstations, wherein each guiding duct is adapted to receive drug portionsdispensed from at least one of the dosing stations when the guiding ductis positioned at the at least one dosing station, and to guide thereceived drug portions to a passage opening of the guiding duct, aplurality of collecting containers coupled to the transport means sothat each collecting container can be positioned at the passage openingof one of the guiding ducts to receive drug portions guided through theguiding duct, at least one discharge and packaging station fortransferring drug portions collected by each collecting container to apackaging and for closing the packaging.
 2. The system as claimed inclaim 1, wherein the dosing stations are arranged in a plurality ofparallel columns, each column comprising a plurality of dosing stations,wherein each guiding duct is adapted to receive drug portions dispensedfrom the dosing stations of a column when the guiding duct is positionedat the column of dosing station.
 3. The system as claimed in claim 2,wherein the dosing stations are arranged in a plurality of verticalcolumns and each guiding duct consists of a vertical fall tube.
 4. Thesystem as claimed in claim 3, wherein the width of a fall tube in thetransport direction substantially corresponds to the width of a dosingstation.
 5. The system as claimed in claim 1, wherein the transportmeans comprises a first endless conveyor and a second endless conveyor,the guiding ducts being coupled to the first endless conveyor and thecollecting containers being coupled to the second endless conveyor. 6.The system as claimed in claim 5, wherein the first endless conveyorcomprises two parallel endless conveyor belts.
 7. The system as claimedin claim 5, wherein the system comprises drive means for driving thefirst endless conveyor and the second endless conveyor with the sametransport speed.
 8. The system as claimed in claim 7, wherein the firstconveyor and the second conveyor are coupled mechanically to each other.9. The system as claimed in claim 5, wherein the width of a collectingcontainer in the transport direction substantially corresponds to thewidth of a guiding duct in the transport direction.
 10. The system asclaimed in claim 5, wherein the physical length of the second conveyoris greater than the length of the first conveyor so that the number ofcollecting containers coupled to the second conveyor is greater than thenumber of fall tubes coupled to the first conveyor.
 11. The system asclaimed in claim 5, wherein each fall tube is detachably coupled to thefirst conveyor.
 12. The system as claimed in claim 5, wherein eachcollecting container is detachably coupled to the second conveyor. 13.The system as claimed in claim 1, wherein an underside of eachcollecting container comprises a controllable closing element to enableremoval of the collected drug portions from the collecting container.14. The system as claimed in claim 12, wherein the closing elements aremechanically displaceable by the discharge and packaging station. 15.The system as claimed in claim 10, wherein the system also comprises atleast one special dosing station for dispensing less frequently applieddrug portions, the special dosing station being positioned relative tothe second conveyor such that drug portions delivered by the specialdosing station can be received directly in a collecting containerpositioned at the special dosing station.
 16. The system as claimed inclaim 1, wherein each dosing station comprises a supply containerreceiving a plurality of solid drug portions and a dosing deviceconnecting to the supply container, wherein the dosing device is adaptedto separate a single solid drug portion from the solid drug portionspresent in the supply container.
 17. The system as claimed in claim 16,wherein the dosing device is movable relative to the supply containerbetween a loading state, in which a receiving space of the dosing deviceconnects to a delivery opening of the supply container, and an unloadingstate in which the dosing device covers the delivery opening and isadapted to deliver the separated solid drug portion to a guiding ductpositioned at an outlet of the dosing station.
 18. The system as claimedin claim 17, wherein the dosing station comprises an electric motor, inparticular a stepper motor, for moving the dosing device relative to thesupply container, and a measuring element for measuring the resistanceproduced by the electric motor.
 19. The system as claimed in claim 16,wherein the dosing device comprises an indicator for generating a signalwhen the degree of filling of the supply container falls below apredefined minimum value.
 20. The system as claimed in claim 18, whereinthe dosing station comprises a station control for dispensing a dosedquantity of solid drug portions on demand, wherein the station controlis adapted to reverse the electric motor, if the resistance detected bythe measuring element exceeds a predefined value.
 21. The system asclaimed in claim 17, wherein the dosing device comprises a rotatingindividualizing wheel mounted in the supply container.
 22. The system asclaimed in claim 16, wherein the dosing device comprises a sensor fordetecting the moment at which a solid drug portion is dispensed by thedosing station.
 23. The system as claimed in claim 1, wherein the systemcomprises a control unit for controlling the discharge and packagingstation, the dosing stations, and the transport means, wherein thecontrol unit is adapted to determine, on the basis of a desired dosedquantity of drug portions for packaging, a dosed quantity of drugportions to be successively dispensed through time by a plurality ofdosing stations via the fall tubes to the collecting containers.
 24. Amethod for dosing solid drug portions, comprising: receiving aprescription with a desired quantity of solid drug portions, determiningon the basis of the prescription the quantity of solid drug portions tobe dispensed by at least one dosing station to a selected collectingcontainer, moving at least one guiding duct by the transport means andhaving the at least one dosing station dispense the determined quantityof drug portions to a guiding duct moving along the at least one dosingstation for the purpose of guiding the dispensed solid drug portions tothe selected collecting container, moving the selected collectingcontainer via the transport means to a discharge and packaging station,and delivering the dosed quantity of solid drug portions by via thecollecting container into the discharge and packaging station.
 25. Themethod as claimed in claim 24, further comprising packaging the dosedquantity of solid drug portions delivered by the collecting containerinto the discharge and packaging station.
 26. The method as claimed inclaim 24, wherein receiving a prescription with a desired quantity ofsolid drug portions comprises receiving a plurality of prescriptions,and further comprising linking each prescription to a selectedcollecting container.
 27. The method as claimed in claim 2 furthercomprising discarding the drug portions collected by a collectingcontainer when a sensor detects that insufficient medicine is beingdelivered to the collecting container.